Estradiol Elevates Protein Kinase C Catalytic Activity in the Preoptic Area of Female Rats1

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Estradiol elevates protein kinase C catalytic activity in the preoptic area of female rats.

Estrogen acts in the brain to regulate female reproductive physiology and behavior, and protein kinase C (PKC) is estrogen-regulated in many estrogen-responsive tissues. We examined whether estrogen regulates PKC in the hypothalamus (HYP) and preoptic area (POA), brain regions which mediate estrogenic control of female reproductive function. PKC activity in tissue from hormone-treated and contr...

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Electrical stimulation of the preoptic area (POA) interrupts the lordosis reflex, a combined contraction of back muscles, in response to male mounts and the major receptive component of sexual behavior in female rat in estrus, without interfering with the proceptive component of this behavior or solicitation. Axon-sparing POA lesions with an excitotoxin, on the other hand, enhance lordosis and ...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 1998

ISSN: 0013-7227,1945-7170

DOI: 10.1210/endo.139.7.6088